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Accueil du site > Équipes > Équipe 1 RNA, RNP : Structure-Fonction-Maturation



  • Galvanin A, Dostert G, Ayadi L, Marchand V, Velot É, Motorin Y. Diversity and heterogeneity of extracellular RNA in human plasma. Biochimie. 2019 May 17. pii: S0300-9084(19)30150-6. doi: 10.1016/j.biochi.2019.05.011.
    PMID: 31108123
  • Freund I, Buhl DK, Boutin S, Kotter A, Pichot F, Marchand V, Vierbuchen T, Heine H, Motorin Y, Helm M, Dalpke AH, Eigenbrod T. 2'-O-methylation within prokaryotic and eukaryotic tRNA inhibits innate immune activation by endosomal Toll-like receptors but does not affect recognition of whole organisms. RNA. 2019 Apr 24. pii: rna.070243.118. doi: 10.1261/rna.070243.118.
    PMID: 31019095
  • Massenet S. In vivo assembly of eukaryotic signal recognition particle: A still enigmatic process involving the SMN complex. Biochimie. 2019 Apr 9. pii: S0300-9084(19)30109-9. doi: 10.1016/j.biochi.2019.04.007.
    PMID: 30978374
  • Chagot ME, Quinternet M, Rothé B, Charpentier B, Coutant J, Manival X, Lebars I. The yeast C/D box snoRNA U14 adopts a "weak" K-turn like conformation recognized by the Snu13 core protein in solution. Biochimie. 2019 Mar 23. pii: S0300-9084(19)30083-5. doi: 10.1016/j.biochi.2019. 03.014.
    PMID: 30914254
  • Paul A, Tiotiu D, Bragantini B, Marty H, Charpentier B, Massenet S, Labialle S. Bcd1p controls RNA loading of the core protein Nop58 during C/D box snoRNP biogenesis. RNA. 2019 Apr;25(4):496-506. doi: 10.1261/rna.067967.118.
    PMID: 30700579
  • Jacob D, Thüring K, Galliot A, Marchand V, Galvanin A, Ciftci A, Scharmann K, Stock M, Roignant JY, Leidel SA, Motorin Y, Schaffrath R, Klassen R, Helm M. Absolute quantification of noncoding RNA by microscale thermophoresis.Angew Chem Int Ed Engl. 2019 Mar 20. doi: 10.1002/anie.201814377.
    PMID: 30892798.
  • Wei J, Kishton RJ, Angel M, Conn CS, Dalla-Venezia N, Marcel V, Vincent A, Catez F, Ferré S, Ayadi L, Marchand V, Dersh D, Gibbs JS, Ivanov IP, Fridlyand N, Couté Y, Diaz JJ, Qian SB, Staudt LM, Restifo NP, Yewdell JW. Ribosomal Proteins Regulate MHC Class I Peptide Generation for Immunosurveillance. Mol Cell. 2019 Jan 24. pii: S1097-2765(18)31096-7. doi: 10.1016/j.molcel.2018.12.020.
    PMID: 30712990.
  • Motorin Y, Helm M. Methods for RNA Modification Mapping Using Deep Sequencing: Established and New Emerging Technologies. Genes (Basel). 2019 Jan 9;10(1). pii: E35. doi: 10.3390/genes10010035. Review.
    PMID: 30634534.
  • Ringeard M, Marchand V, Decroly E, Motorin Y, Bennasser Y. FTSJ3 is an RNA 2'-O-methyltransferase recruited by HIV to avoid innate immune sensing. Nature. 2019 Jan 9. doi: 10.1038/s41586-018-0841-4. 
  • Galvanin A, Ayadi L, Helm M, Motorin Y, Marchand V. Mapping and Quantification of tRNA 2'-O-Methylation by RiboMethSeq. Methods Mol Biol. 2019;1870:273-295. doi: 10.1007/978-1-4939-8808-2_21.
    PMID:  30539563


  • Ayadi L, Galvanin A, Pichot F, Marchand V, Motorin Y.  RNA ribose methylation (2'-O-methylation): Occurrence, biosynthesis and biological functions. Biochim Biophys Acta Gene Regul Mech. 2018 Dec 17. pii: S1874-9399(18)30080-4. doi: 10.1016/j.bbagrm.2018.11.009. 
    PMID: 30572123
  • Motorin Y, Marchand V. Detection and Analysis of RNA Ribose 2'-O-Methylations: Challenges and Solutions. Genes (Basel). 2018 Dec 18;9(12). pii: E642. doi: 10.3390/genes9120642.
    PMID: 30567409
  • Marchand V, Ayadi L, Ernst FGM, Hertler J, Bourguignon-Igel V, Galvanin A, Kotter A, Helm M, Lafontaine DLJ, Motorin Y. AlkAniline-Seq: profiling of m7G and m3C RNA modifications at single nucleotide resolution. Angew Chem Int Ed Engl. 2018 Oct 29. doi: 10.1002/anie.201810946
    PMID: 30370969
  • Fujikane R, Behm-Ansmant I, Tillault AS, Loegler C, Igel-Bourguignon V, Marguet E, Forterre P, Branlant C, Motorin Y, Charpentier B.  Contribution of protein Gar1 to the RNA-guided and RNA-independent rRNA:Ψ-synthase activities of the archaeal Cbf5 protein.Sci Rep. 2018 Sep 14;8(1):13815. doi: 10.1038/s41598-018-32164-0.
  • Keller P, Freund I, Marchand V, Bec G, Huang R, Motorin Y, Eigenbrod T, Dalpke A, Helm M. Double methylation of tRNA-U54 to 2'-O-methylthymidine (Tm) synergistically decreases immune response by Toll-like receptor 7. Nucleic Acids Res. 2018 Aug 8. doi: 10.1093/nar/gky644. [Epub ahead of print]. 
  • Henri J, Chagot ME, Bourguet M, Abel Y, Terral G, Maurizy C, Aigueperse C, Georgescauld F, Vandermoere F, Saint-Fort R, Behm-Ansmant I, Charpentier B, Pradet-Balade B, Verheggen C, Bertrand E, Meyer P, Cianférani S, Manival X, Quinternet M. Deep Structural Analysis of RPAP3 and PIH1D1, Two Components of the HSP90 Co-chaperone R2TP Complex. Structure. 2018 Jul 18. pii: S0969-2126(18)30208-9. doi: 10.1016/j.str.2018.06.002.  PMID:30033218
  • Jantsch MF, Quattrone A, O'Connell M, Helm M, Frye M, Macias-Gonzales M, Ohman M, Ameres S, Willems L, Fuks F, Oulas A, Vanacova S, Nielsen H, Bousquet-Antonelli C, Motorin Y, Roignant JY, Balatsos N, Dinnyes A, Baranov P, Kelly V, Lamm A, Rechavi G, Pelizzola M, Liepins J, Holodnuka Kholodnyuk I, Zammit V, Ayers D, Drablos F, Dahl JA, Bujnicki J, Jeronimo C, Almeida R, Neagu M, Costache M, Bankovic J, Banovic B, Kyselovic J, Valor LM, Selbert S, Pir P, Demircan T, Cowling V, Schäfer M, Rossmanith W, Lafontaine D, David A, Carre C, Lyko F, Schaffrath R, Schwartz S, Verdel A, Klungland A, Purta E, Timotijevic G, Cardona F, Davalos A, Ballana E, O Carroll D, Ule J, Fray R. Positioning Europe for the EPITRANSCRIPTOMICS challenge. RNA Biol. 2018 May 9:1-3. doi: 10.1080/15476286.2018.1460996. 
  • Maurizy C, Quinternet M, Abel Y, Verheggen C, Santo PE, Bourguet M, C F Paiva A, Bragantini B, Chagot ME, Robert MC, Abeza C, Fabre P, Fort P, Vandermoere F, M F Sousa P, Rain JC, Charpentier B, Cianférani S, Bandeiras TM, Pradet-Balade B, Manival X, Bertrand E. The RPAP3-Cterminal domain identifies R2TP-like quaternary chaperones. Nat Commun. 2018 May 29;9(1):2093. doi: 10.1038/s41467-018-04431-1. 
  • Dal Magro C, Keller P, Kotter A, Werner S, Duarte V, Marchand V, Ignarski M, Freiwald A, Müller RU, Dieterich C, Motorin Y, Butter F, Atta M, Helm M. A vastly increased chemical variety of RNA modifications that includes a thioacetal structure. Angew Chem Int Ed Engl. 2018 Apr 6. doi: 10.1002/anie.201713188.
    PMID: 29624844
  • Bragantini B, Rouillon C, Charpentier B, Manival X, Quinternet M. NMR assignment and solution structure of the external DII domain of the yeast Rvb2 protein. Biomol NMR Assign. 2018 Mar 22. doi: 10.1007/s12104-018-9816-5.
    PMID: 29569106
  • Weldon C, Dacanay JG, Gokhale V, Boddupally PVL, Behm-Ansmant I, Burley GA, Branlant C, Hurley LH, Dominguez C, Eperon IC.  Specific G-quadruplex ligands modulate the alternative splicing of Bcl-X.  Nucleic Acids Res. 2018 Jan 25;46(2):886-896. doi: 10.1093/nar/gkx1122.
    PMID: 29156002
  • Ayadi L, Motorin Y, Marchand V. Quantification of 2'-O-Me Residues in RNA Using Next-Generation Sequencing (Illumina RiboMethSeq Protocol). Methods Mol Biol. 2018;1649:29-48. doi: 10.1007/978-1-4939-7213-5_2.
  • Guéant JL, Chéry C, Oussalah A, Nadaf J, Coelho D, Josse T, Flayac J, Robert A, Koscinski I, Gastin I, Filhine-Tresarrieu P, Pupavac M, Brebner A, Watkins D, Pastinen T, Montpetit A, Hariri F, Tregouët D, Raby BA, Chung WK, Morange PE, Froese DS, Baumgartner MR, Benoist JF, Ficicioglu C, Marchand V, Motorin Y, Bonnemains C, Feillet F, Majewski J, Rosenblatt DS. A PRDX1 mutant allele causes a MMACHC secondary epimutation in cblC patients. Nat Commun. 2018 Jan 4;9(1):67. doi: 10.1038/s41467-017-02306-5. Erratum in: Nat Commun. 2018 Feb 2;9(1):554.
    PMID: 29302025
  • Aschenbrenner J, Werner S, Marchand V, Adam M, Motorin Y, Helm M, Marx A.  Engineering of a DNA Polymerase for Direct m6A Sequencing. Angew Chem Int Ed Engl. 2018 Jan 8;57(2):417-421. doi: 10.1002/anie.201710209. Epub 2017 Dec 7.
    PMID: 29115744


  • Erales J, Marchand V, Panthu B, Gillot S, Belin S, Ghayad SE, Garcia M, Laforêts F, Marcel V, Baudin-Baillieu A, Bertin P, Couté Y, Adrait A, Meyer M, Therizols G, Yusupov M, Namy O, Ohlmann T, Motorin Y, Catez F, Diaz JJ. Evidence for rRNA 2'-O-methylation plasticity: Control of intrinsic translational capabilities of human ribosomes. Proc Natl Acad Sci U S A. 2017 Dec 5;114(49):12934-12939. doi: 10.1073/pnas.1707674114. Epub 2017 Nov 20.
    PMID: 29158377
  • Sharma S, Marchand V, Motorin Y, Lafontaine DLJ. Identification of sites of 2'-O-methylation vulnerability in human ribosomal RNAs by systematic mapping. Sci Rep. 2017 Sep 13;7(1):11490. doi: 10.1038/s41598-017-09734-9.
    PMID: 28904332
  • Weldon C, Behm-Ansmant I, Hurley LH, Burley GA, Branlant C, Eperon IC, Dominguez C.  Identification of G-quadruplexes in long functional RNAs using 7-deazaguanine RNA. Nat Chem Biol. 2017 Jan;13(1):18-20. doi: 10.1038/nchembio.2228. Epub 2016 Nov 7.
  • Moulin D, Salone V, Koufany M, Clément T, Behm-Ansmant I, Branlant C, Charpentier B, Jouzeau JY. MicroRNA-29b Contributes to Collagens Imbalance in Human Osteoarthritic and Dedifferentiated Articular Chondrocytes. Biomed Res Int. 2017;2017:9792512. doi: 10.1155/2017/9792512. Epub 2017 May 22.
    PMID: 28612031
  • Helm M, Motorin Y. Detecting RNA modifications in the epitranscriptome: predict and validate. Nat Rev Genet. 2017 May;18(5):275-291. doi: 10.1038/nrg.2016.169. Epub 2017 Feb 20. Review.
  • Marchand V, Pichot F, Thüring K, Ayadi L, Freund I, Dalpke A, Helm M, Motorin Y. Next-Generation Sequencing-Based RiboMethSeq  Protocol for Analysis of tRNA 2'-O-Methylation. Biomolecules. 2017 Feb 9;7(1). pii: E13. doi: 10.3390/biom7010013.
  • Marchand V, Ayadi L, El Hajj A, Blanloeil-Oillo F, Helm M, Motorin Y. High-Throughput Mapping of 2'-O-Me Residues in RNA Using Next-Generation Sequencing (Illumina RiboMethSeq Protocol).  Methods Mol Biol. 2017;1562:171-187. doi: 10.1007/978-1-4939-6807-7_12.
  • Gribling-Burrer AS, Leichter M, Wurth L, Huttin A, Schlotter F, Troffer-Charlier N, Cura V, Barkats M, Cavarelli J, Massenet S, Allmang C. SECIS-binding protein 2 interacts with the SMN complex and the methylosome for selenoprotein mRNP assembly and translation. Nucleic Acids Res. 2017 Jan 23. pii: gkx031. doi: 10.1093/nar/gkx031.
  • Rothé B, Manival X, Rolland N, Charron C, Senty-Ségault V, Branlant C, Charpentier B. Implication of the box C/D snoRNP assembly factor Rsa1p in U3 snoRNP assembly. Nucleic Acids Res. 2017 May 13. doi: 10.1093/nar/gkx424.
  • Schwartz S, Motorin Y. (2016) Next-generation sequencing technologies for detection of modified nucleotides in RNAs. RNA Biol. 2017 Sep 2;14(9):1124-1137. doi: 10.1080/15476286.2016.1251543. Epub 2016 Oct 28.
    PMID: 27791472


  • Hauenschild R, Werner S, Tserovski L, Hildebrandt A, Motorin Y, Helm M. (2016) CoverageAnalyzer (CAn): A Tool for Inspection of Modification Signatures in RNA Sequencing Profiles. Biomolecules. 2016 Nov 10;6(4). pii: E42.
  • Massenet S, Bertrand E, Verheggen C (2016) Assembly and trafficking of box C/D and H/ACA snoRNPs. RNA Biol. 2016 Oct 7:1-13. doi: 10.1080/15476286.2016.1243646. PMID:27715451
  • Tserovski L, Marchand V, Hauenschild R, Blanloeil-Oillo F, Helm M, Motorin Y. High-throughput sequencing for 1-methyladenosine (m(1)A) mapping in RNA. Methods. 2016 Sep 1;107:110-21. doi: 10.1016/j.ymeth.2016.02.012. Epub 2016 Feb 24. PMID: 26922842 

  • BRAGANTINI B.$; TIOTIU D.$; ROTHE B.; SALIOU J. M.; MARTY H.; CIANFERANI S.; CHARPENTIER B.; QUINTERNET M. and MANIVAL X.* (2016). Functional and structural insights of the Zinc-Finger HIT protein family members involved in Box C/D snoRNP biogenesis. Journal of Molecular Biology, 428: 2488-2506.
  • Marchand V, Blanloeil-Oillo F, Helm M, Motorin Y.* (2016). Illumina-based RiboMethSeq approach for mapping of 2'-O-Me residues in RNA. Nucleic Acids Research, 2016 Sep 19;44(16):e135. doi: 10.1093/nar/gkw547. Epub 2016 Jun 14.
  • Motorin Y, Seidu-Larry S, Helm M. (2016). DNA and RNA pyrimidine nucleobase alkylation at the carbon-5 position. DNA Methyltransferases - Role and Function. Ed Prof. Dr. Albert Jeltsch and Dr. Renata Z. Jurkowska, Springer. Adv Exp Med Biol. 2016;945:19-33. Review. PMID: 27826833


  • BIZARRO J.; DODRE M.; HUTTIN A.; CHARPENTIER B.; SCHLOTTER F.; BRANLANT C.; VERHEGGEN C.*; MASSENET S.* and BERTRAND E.* (2015). NUFIP and the HSP90/R2TP chaperone bind the SMN complex and facilitate assembly of U4-specific proteins. Nucleic Acids Research, 43: 8973-8989.
  • BOURGEOIS G.$; NEY M.$; GASPAR I.; AIGUEPERSE C.; SCHAEFER M.; KELLNER S.; HELM M. and MOTORIN Y.* (2015). Eukaryotic rRNA Modification by Yeast 5-Methylcytosine-Methyltransferases and Human Proliferation-Associated Antigen p120. PloS One, 10: e0133321.
  • HAUENSCHILD R.$; TSEROVSKI L.$; SCHMID K.; THURING K.; WINZ M. L.; SHARMA S.; ENTIAN K. D.; WACHEUL L.; LAFONTAINE D. L.; ANDERSON J.; ALFONZO J.; HILDEBRANDT A.; JASCHKE A.; MOTORIN Y.* and HELM M.* (2015). The reverse transcription signature of N-1-methyladenosine in RNA-Seq is sequence dependent. Nucleic Acids Research, 43: 9950-9964.
  • MANIVAL X.; JACQUEMIN C.; CHARPENTIER B. and QUINTERNET M.* (2015). (1)H, (15)N and (13)C resonance assignments of the yeast Pih1 and Tah1 C-terminal domains complex. Biomolecular NMR Assignments, 9: 71-73.
  • QUINTERNET M.; ROTHE B.; BARBIER M.; BOBO C.; SALIOU J. M.; JACQUEMIN C.; BACK R.; CHAGOT M. E.; CIANFERANI S.; MEYER P.; BRANLANT C.; CHARPENTIER B. and MANIVAL X.* (2015). Structure/Function Analysis of Protein-Protein Interactions Developed by the Yeast Pih1 Platform Protein and Its Partners in Box C/D snoRNP Assembly. Journal of Molecular Biology, 427: 2816-2839.
  • SALIOU J. M.; MANIVAL X.; TILLAULT A. S.; ATMANENE C.; BOBO C.; BRANLANT C.; VAN DORSSELAER A.; CHARPENTIER B. and CIANFERANI S.* (2015). Combining native MS approaches to decipher archaeal box H/ACA ribonucleoprotein particle structure and activity. Proteomics, 15: 2851-2861.
  • CHAGOT M. E.; JACQUEMIN C.; BRANLANT C.; CHARPENTIER B.; MANIVAL X. and QUINTERNET M.* (2015). (1)H, (15)N and (13)C resonance assignments of the two TPR domains from the human RPAP3 protein. Biomolecular NMR Assignments, 9: 99-102.
  • TILLAULT A. S.$; FOURMANN J. B.$; LOEGLER C.; BLAUD M.; BRANLANT C. and CHARPENTIER B.* (2015). RNA size is a critical factor for U-containing substrate selectivity and permanent pseudouridylated product release during the RNA:Psi-synthase reaction catalyzed by box H/ACA sRNP enzyme at high temperature. Biochimie, 113: 134-142.
  • TILLAULT A. S.$; FOURMANN J. B.$; LOEGLER C.; WIEDEN H. J.; KOTHE U. and CHARPENTIER B.* (2015). Contribution of two conserved histidines to the dual activity of archaeal RNA guide-dependent and -independent pseudouridine synthase Cbf5. RNA, 21: 1233-1239.
  • VAUTROT V.; AIGUEPERSE C.; OILLO-BLANLOEIL F.; HUPONT S.; STEVENIN J.; BRANLANT C.* and BEHM-ANSMANT I.* (2015). Enhanced SRSF5 Protein Expression Reinforces Lamin A mRNA Production in HeLa Cells and Fibroblasts of Progeria Patients. Human Mutation, 37: 280-291.
  • ABEL Y. and REDERSTORFF M. (2015). Gene expression knockdown by transfection of siRNAs into mammalian cells. Methods in Molecular Biology, 1296: 199-202.
  • CLEMENT T.; SALONE V. and REDERSTORFF M. (2015). Dual luciferase gene reporter assays to study miRNA function. Methods in Molecular Biology, 1296: 187-198.
  • CLERGET G.; ABEL Y. and REDERSTORFF M. (2015). Small non-coding RNAs: a quick look in the rearview mirror. Methods in Molecular Biology, 1296: 3-9.
  • CLERGET G.; BOURGUIGNON-IGEL V. and REDERSTORFF M. (2015). Alcoholic precipitation of small non-coding RNAs. Methods in Molecular Biology, 1296: 11-16.
  • MARCHAND V. and BRANLANT C. (2015). Quantification and quality control of a small non-coding RNA preparation. Methods in Molecular Biology, 1296: 17-28.
  • MOTORIN Y. (2015) RNA Modification In: Encyclopedia of Life Sciences (eLS). John Wiley& Sons, Ltd: Chichester. DOI: 10.1002/9780470015902.a0000528.pub3.
  • PHILIPPE J. V.; AYADI L.; BRANLANT C. and BEHM-ANSMANT I. (2015). Probing small non-coding RNAs structures. Methods in Molecular Biology, 1296: 119-136.
  • REDERSTORFF M. (EDITOR). (2015). Small non-coding RNA, methods and protocols. Methods in Molecular Biology, 1296.
  • SALONE V. and REDERSTORFF M. (2015). Stem-loop RT-PCR based quantification of small non-coding RNAs. Methods in Molecular Biology, 1296: 103-108.
  • VAUTROT V.; AIGUEPERSE C.; BRANLANT C. and BEHM-ANSMANT I. (2015). Fluorescence in situ hybridization of small non-coding RNAs. Methods in Molecular Biology, 1296: 73-83.


  • BIZARRO J.$; CHARRON C.$; BOULON S.; WESTMAN B.; PRADET-BALADE B.; VANDERMOERE F.; CHAGOT M. E.; HALLAIS M.; AHMAD Y.; LEONHARDT H.; LAMOND A.; MANIVAL X.; BRANLANT C.; CHARPENTIER B.; VERHEGGEN C.* and BERTRAND E.* (2014). Proteomic and 3D structure analyses highlight the C/D box snoRNP assembly mechanism and its control. The Journal of Cell Biology, 207: 463-480.
  • CARPENTIER C.; GHANEM D.; FERNANDEZ-GOMEZ F. J.; JUMEAU F.; PHILIPPE J. V.; FREYERMUTH F.; LABUDECK A.; EDDARKAOUI S.; DHAENENS C. M.; HOLT I.; BEHM-ANSMANT I.; MARMIER-GOURRIER N.; BRANLANT C.; CHARLET-BERGUERAND N.; MARIE J.; SCHRAEN-MASCHKE S.; BUEE L.; SERGEANT N.* and CAILLET-BOUDIN M. L.* (2014). Tau exon 2 responsive elements deregulated in myotonic dystrophy type I are proximal to exon 2 and synergistically regulated by MBNL1 and MBNL2. Biochimica et Biophysica Acta, 1842: 654-664. Q1
  • ROTHE B.; BACK R.; QUINTERNET M.; BIZARRO J.; ROBERT M. C.; BLAUD M.; ROMIER C.; MANIVAL X.*; CHARPENTIER B.*; BERTRAND E.* and BRANLANT C. (2014). Characterization of the interaction between protein Snu13p/15.5K and the Rsa1p/NUFIP factor and demonstration of its functional importance for snoRNP assembly. Nucleic Acids Research, 42: 2015-2036.
  • ROTHE B.; SALIOU J. M.; QUINTERNET M.; BACK R.; TIOTIU D.; JACQUEMIN C.; LOEGLER C.; SCHLOTTER F.; PENA V.; ECKERT K.; MORERA S.; DORSSELAER A. V.; BRANLANT C.*; MASSENET S.; SANGLIER-CIANFERANI S.; MANIVAL X. and CHARPENTIER B.* (2014). Protein Hit1, a novel box C/D snoRNP assembly factor, controls cellular concentration of the scaffolding protein Rsa1 by direct interaction. Nucleic Acids Research, 42: 10731-10747.
  • CLEMENT T.; SALONE V.; CHARPENTIER B.; JOUZEAU J. Y. and BIANCHI A. (2014). Identification of new microRNAs targeting genes regulating the Pi/PPi balance in chondrocytes. Bio-medical Materials and Engineering, 24: 3-16.
  • MOTORIN Y.* and CHARPENTIER B. (2014). RNA Modification. Reviews in cell biology and molecular medicine (Encyclopedia of Molecular Cell Biology and Molecular Medicine), 1-47.
  • SPENKUCH F.; MOTORIN Y. and HELM M.* (2014). Pseudouridine: still mysterious, but never a fake (uridine)! RNA Biology, 11: 1540-1554.
  • MARCHAND V.; MOUGIN A.; MEREAU A.; BEHM-ANSMANT I.; MOTORIN Y.; and BRANLANT C. (2014). Study of RNA-Protein Interactions and RNA Structure in Ribonucleoprotein Particles. Handbook of RNA Biochemistry, Second, completely revised and enlarged Edition, Edited by HARTMANN R. K.; BINDEREIF A.; SCHON A.; and WESTHOF E.; Wiley-VCH Verlag GmbH and Co. KGaA, Volume 2, chapter 44, 975-1015.
  • ABEL Y.; CLERGET G.; BOURGUIGNON-IGEL V.; SALONE V. and REDERSTORFF M.* (2014). Beyond usual functions of snoRNAs. Medecine Sciences : M/S, 30: 297-302.


  • BACK R.; DOMINGUEZ C.; ROTHE B.; BOBO C.; BEAUFILS C.; MORERA S.; MEYER P.; CHARPENTIER B.; BRANLANT C.; ALLAIN F. H.* and MANIVAL X.* (2013). High-resolution structural analysis shows how Tah1 tethers Hsp90 to the R2TP complex. Structure, 21: 1834-1847.
  • BOS J.; DUVERGER Y.; THOUVENOT B.; CHIARUTTINI C.; BRANLANT C.; SPRINGER M.; CHARPENTIER B. and BARRAS F.* (2013). The sRNA RyhB regulates the synthesis of the Escherichia coli methionine sulfoxide reductase MsrB but not MsrA. PloS One, 8: e63647.
  • FOURMANN J. B.$; TILLAULT A. S.$; BLAUD M.$; LECLERC F.; BRANLANT C. and CHARPENTIER B.* (2013). Comparative study of two box H/ACA ribonucleoprotein pseudouridine-synthases: relation between conformational dynamics of the guide RNA, enzyme assembly and activity. PloS One, 8: e70313.
  • PIAZZON N.; SCHLOTTER F.; LEFEBVRE S.; DODRE M.; MEREAU A.; SORET J.; BESSE A.; BARKATS M.; BORDONNE R.; BRANLANT C. and MASSENET S.* (2013). Implication of the SMN complex in the biogenesis and steady state level of the signal recognition particle. Nucleic Acids Research, 41: 1255-1272.
  • BOSCHI-MULLER S. and MOTORIN Y. (2013). Chemistry enters nucleic acids biology: enzymatic mechanisms of RNA modification. Biochemistry (Mosc), 78: 1392-1404.


  • MARMIER-GOURRIER N.; VAUTRIN A.; BRANLANT C. and BEHM-ANSMANT I. (2012). Analyses of site-specific RNA-protein interactions. Edited by STAMM S.; SMITH C.; and LUHRMANN R.; Wiley-Blackwell, chapter 32, 343-355.
  • REDERSTORFF M. (2012). Generation of cDNA libraries from RNP-derived regulatory noncoding RNAs. Methods in Molecular Biology, 925: 211-218.
  • SKREKA K. and REDERSTORFF M. (2012). [A hybrid microarray for the analysis of a miscellaneous ncRNA population]. Medecine Sciences : M/S, 28: 819-821.


  • BAR A.; MARCHAND V.; KHOURY G.; DREUMONT N.; MOUGIN A.; ROBAS N.; STEVENIN J.; VISVIKIS A. and BRANLANT C.* (2011). Structural and functional analysis of the Rous Sarcoma virus negative regulator of splicing and demonstration of its activation by the 9G8 SR protein. Nucleic Acids Research, 39: 3388-3403.
  • KELLNER S.; SEIDU-LARRY S.; BURHENNE J.; MOTORIN Y. and HELM M.* (2011). A multifunctional bioconjugate module for versatile photoaffinity labeling and click chemistry of RNA. Nucleic Acids Research, 39: 7348-7360.
  • LOPEZ-MEJIA I. C.; VAUTROT V.; DE TOLEDO M.; BEHM-ANSMANT I.; BOURGEOIS C. F.; NAVARRO C. L.; OSORIO F. G.; FREIJE J. M.; STEVENIN J.; DE SANDRE-GIOVANNOLI A.; LOPEZ-OTIN C.; LEVY N.; BRANLANT C. and TAZI J.* (2011). A conserved splicing mechanism of the LMNA gene controls premature aging. Human Molecular Genetics, 20: 4540-4555.
  • MARCHAND V.$; SANTERRE M.$; AIGUEPERSE C.; FOUILLEN L.; SALIOU J. M.; VAN DORSSELAER A.; SANGLIER-CIANFERANI S.; BRANLANT C.* and MOTORIN Y. (2011). Identification of protein partners of the human immunodeficiency virus 1 tat/rev exon 3 leads to the discovery of a new HIV-1 splicing regulator, protein hnRNP K. RNA Biology, 8: 325-342.
  • MARMIER-GOURRIER N.$; CLERY A.$; SCHLOTTER F.; SENTY-SEGAULT V. and BRANLANT C.* (2011). A second base pair interaction between U3 small nucleolar RNA and the 5'-ETS region is required for early cleavage of the yeast pre-ribosomal RNA. Nucleic Acids Research, 39: 9731-9745.
  • MOTORIN Y.; BURHENNE J.; TEIMER R.; KOYNOV K.; WILLNOW S.; WEINHOLD E. and HELM M.* (2011). Expanding the chemical scope of RNA:methyltransferases to site-specific alkynylation of RNA for click labeling. Nucleic Acids Research, 39: 1943-1952.
  • TRAN H.$; GOURRIER N.$; LEMERCIER-NEUILLET C.$; DHAENENS C. M.; VAUTRIN A.; FERNANDEZ-GOMEZ F. J.; ARANDEL L.; CARPENTIER C.; OBRIOT H.; EDDARKAOUI S.; DELATTRE L.; VAN BRUSSELS E.; HOLT I.; MORRIS G. E.; SABLONNIERE B.; BUEE L.; CHARLET-BERGUERAND N.; SCHRAEN-MASCHKE S.; FURLING D.; BEHM-ANSMANT I.; BRANLANT C.; CAILLET-BOUDIN M. L. and SERGEANT N.* (2011). Analysis of exonic regions involved in nuclear localization, splicing activity, and dimerization of Muscleblind-like-1 isoforms. The Journal of Biological Chemistry, 286: 16435-16446.
  • BEHM-ANSMANT I.; HELM M. and MOTORIN Y.* (2011). Use of specific chemical reagents for detection of modified nucleotides in RNA. Journal of nucleic acids, 2011: 408053.
  • MOTORIN Y.* and HELM M. (2011). RNA nucleotide methylation. Wiley interdisciplinary reviews. RNA, 2: 611-631.


  • DREUMONT N.; HARDY S.; BEHM-ANSMANT I.; KISTER L.; BRANLANT C.; STEVENIN J.; BOURGEOUS C. F. (2010) Antagonistic factors control the unproductive splicing of SC35 terminal intron. Nucleic Acids Res 38: 1353-1366
  • MAENNER S.; BLAUD M.; FOUILLEN L.; SAVOYE A..; MARCHAND V.; DUBOIS A.; SANGLIER-CIANFERANI S.; VAN DORSSELAER A.; CLERC P.; AVNER P.; VISVIKIS A.; BRANLANT C.(2010) 2-D structure of the A region of Xist RNA and its implication for PRC2 association. PLoS Biol 8: e1000276
  • MOTORIN Y.; HELM M. (2010) tRNA stabilization by modified nucleotides. Biochemistry 49: 4934-4944
  • MOTORIN Y.; LYKO F.; HELM M. (2010) 5-methylcytosine in RNA: detection, enzymatic formation and biological functions. Nucleic Acids Res 38: 1415-1430
  • TAZI J.; BAKKOUR N.; MARCHAND V.; AYADI L.; ABOUFIRASSI A.; BRANLANT C. (2010) Alternative splicing: regulation of HIV-1 multiplication as a target for therapeutic action. FEBS J 277: 867-876


  • MULLER S.; URBAN A.; HECKER A.; LECLERC F.; BRANLANT C.; MOTORIN Y. (2009) Deficiency of the tRNATyr:Psi 35-synthase aPus7 in Archaea of the Sulfolobales order might be rescued by the H/ACA sRNA-guided machinery. Nucleic Acids Res 37: 1308-1322
  • SALIOU J. M.; BOURGEOIS C. F.; AYADI-BEN MENA L.; ROPERS D.; JACQUENET S.; MARCHAND V.; STEVENIN J.; BRANLANT C. (2009) Role of RNA structure and protein factors in the control of HIV-1 splicing. Front Biosci 14: 2714-2729
  • URBAN A.; BEHM-ANSMANT I.; BRANLANT C.; MOTORIN Y. (2009) RNA sequence and two-dimensional structure features required for efficient substrate modification by the Saccharomyces cerevisiae RNA:{Psi}-synthase Pus7p. J Biol Chem 284: 5845-5858


  • BOULON S.; MARMIER-GOURRIER N.; PRADET-BALADE B.; WURTH L.; VERHEGGEN C.; JADY B. E.; ROTHE B.; PESCIA C.; ROBERT M. C.; KISS T.; BARDONI B.; KROL A.; BRANLANT C.; ALLMANG C.; BERTRAND É.; CHARPENTIER B. (2008) The Hsp90 chaperone controls the biogenesis of L7Ae RNPs through conserved machinery. J Cell Biol 180: 579-595
  • MULLER S.; LECLERC F.; BEHM-ANSMANT I.; FOURMANN J. B.; CHARPENTIER B.; BRANLANT C. (2008) Combined in silico and experimental identification of the Pyrococcus abyssi H/ACA sRNAs and their target sites in ribosomal RNAs. Nucleic Acids Res 36: 2459-2475
  • PIAZZON N.; RAGE F.; SCHLOTTER F.; MOINE H.; BRANLANT C.; MASSENET S. (2008) In vitro and in cellulo evidences for association of the survival of motor neuron complex with the fragile X mental retardation protein. J Biol Chem 283: 5598-5610


  • BAKKOUR N.; LIN Y. L.; MAIRE S.; AYADI L.; MAHUTEAU-BETZER F.; NGUYEN C. H.; METTLING C.; PORTALES P.; GRIERSON D.; CHABOT B.; JEANTEUR P.; BRANLANT C.; CORBEAU P.; TAZI J. (2007) Small-molecule inhibition of HIV pre-mRNA splicing as a novel antiretroviral therapy to overcome drug resistance. PLoS Pathog 3: 1530-1539
  • BEHM-ANSMANT I.; BRANLANT C.; MOTORIN Y. (2007) The Saccharomyces cerevisiae Pus2 protein encoded by YGL063w ORF is a mitochondrial tRNA:Psi27/28-synthase. RNA 13: 1641-1647
  • CHARPENTIER B.; FOURMANN J. B.; BRANLANT C. (2007) Reconstitution of archaeal H/ACA sRNPs and test of their activity. Meth Enzymol 425: 389-405
  • CLERY A.; BOURGUIGNON-IGEL V.; ALLMANG C.; KROL A.; BRANLANT C. (2007) An improved definition of the RNA-binding specificity of SECIS-binding protein 2, an essential component of the selenocysteine incorporation machinery. Nucleic Acids Res 35: 1868-1884
  • CLERY A.; SENTY-SEGAULT V.; LECLERC F.; RAHE H. A.; BRANLANT C. (2007) Analysis of sequence and structural features that identify the B/C motif of U3 small nucleolar RNA as the recognition site for the Snu13p-Rrp9p protein pair. Mol Cell Biol 27: 1191-1206
  • MOTORIN Y.; MULLER S.; BEHM-ANSMANT I.; BRANLANT C. (2007) Identification of modified residues in RNAs by reverse transcription-based methods. Meth Enzymol 425: 21-53 -
  • MULLER S.; CHARPENTIER B.; BRANLANT C.; LECLERC F. (2007) A dedicated computational approach for the identification of archaeal H/ACA sRNAs. Meth Enzymol 425: 355-387
  • MULLER S.; FOURMANN J. B.; LOEGLER C.; CHARPENTIER B.; BRANLANT C. (2007) Identification of determinants in the protein partners aCBF5 and aNOP10 necessary for the tRNA:Psi55-synthase and RNA-guided RNA:Psi-synthase activities. Nucleic Acids Res 35: 5610-5624


  • BEHM-ANSMANT I.; MASSENET S.; IMMEL F.; PATTON J. R.; MOTORIN Y.; BRANLANT C.  (2006) A previously unidentified activity of yeast and mouse RNA:pseudouridine synthases 1 (Pus1p) on tRNAs. RNA 12: 1583-1593
  • HALLAY H.; LOCKER N.; AYADI L.; ROPERS D.; GUITTET E.; BRANLANT C. (2006) Biochemical and NMR study on the competition between proteins SC35, SRp40, and heterogeneous nuclear ribonucleoprotein A1 at the HIV-1 Tat exon 2 splicing site. J Biol Chem 281: 37159-37174
  • MANIVAL X.; CHARRON C.; FOURMANN J. B.; GODARD F.; CHARPENTIER B.; BRANLANT C. (2006) Crystal structure determination and site-directed mutagenesis of the Pyrococcus abyssi aCBF5-aNOP10 complex reveal crucial roles of the C-terminal domains of both proteins in H/ACA sRNP activity. Nucleic Acids Res 34: 826-839


  • BARDEY V.; VALLET C.; ROBAS N.; CHARPENTIER B.; THOUVENOT B.; MOUGIN A.; HAJNSDORF E.; REGNIER P.; SPRINGER M.; BRANLANT C. (2005) Characterization of the molecular mechanisms involved in the differential production of erythrose-4-phosphate dehydrogenase, 3-phosphoglycerate kinase and class II fructose-1,6-bisphosphate aldolase in Escherichia coli. Mol Microbiol 57: 1265-1287 
  • CHARPENTIER B.; MULLER S.; BRANLANT C. (2005) Reconstitution of archaeal H/ACA small ribonucleoprotein complexes active in pseudouridylation. Nucleic Acids Res 33: 3133-3144