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Post-doctoral position for medical imaging analysis in osteoarticular domain.

par Astrid Pinzano - 30 avril

Post-doctoral position - 1 year

Location: Vandoeuvre-Lès-Nancy (54) - France

Laboratory: Ingénierie Moléculaire et Physiopathologie Articulaire – UMR 7365 CNRS-UL – Equipe BioReMaTCh (http://www.imopa.cnrs.fr/spip.php?article277)

Contacts: astrid.pinzano@univ-lorraine.fr, d.loeuille@chru-nancy.fr and pierre.gillet@univ-lorraine.fr

Fields and key words: X-Ray, MRI, Osteoarthritis, Score,

Duration: 12 months.

Salary: The full-time monthly gross salary will be between 2130 € and 2948 € depending on experience.

Starting date: Juin or Juillet 2019

Context of the project: The work will take place in Nancy mainly at the IMoPA laboratory in the BioReMaTCh team. "Bio-engineering, Regenerative Medicine and Tissue Characterization" within the UMR 7365 CNRS-UL IMoPA (http://www.imopa.cnrs.fr/spip.php?article277).

This team is composed of 2 statutory researchers, 3 teacher-researchers, 2 engineers (PhD), 1 engineering assistant, 2 technical assistants, 7 clinicians and 1 associate clinician. There are long-standing collaborations with rheumatologist clinicians, orthopaedists and radiologists in the field of multi-method metrology of gonarthrosis. On the clinical level, the team is developing strategies for evaluating osteoarticular pathologies in collaboration with the Rheumatology Department of the CHRU of Nancy.

Imaging reading should be performed on OSIRIX software in the department of Rheumatology (Pr Damien LOEUILLE) and in IMoPA (A PINZANO, PhD, CR CNRS).

Results will be discussed twice a month. The objective is to submit at least three original articles in the year.

Missions: 1) Osteoarthritis is a complex disease involving cartilage, bone and synovial lesions. The standard radiograph is currently the reference examination for the diagnosis and monitoring of structural evolution.

Your mission will be

in knee osteoarthritis: (IMoPA and department of Rheumatology)

·      to collect, record and archive the data from this study

·      to accomplish MOAKS scores using clinical MRI images after validation of the reading quality (reproducibility on the DL referent).

·      to contribute to improving the metrology of osteoarthritis by coupling an MRI acquisition sequence associated with volume reconstruction with the visualization of joint space by EOS.

·      to propose a strategy for modeling cartilage volumes based on MRI sequences.

2) Ankylosing spondylitis (SpA) is a common inflammatory rheumatic disease that affects the axial skeleton, causing characteristic inflammatory back pain.

Your mission will be

in cross sectional studies: (IMoPA and department of Rheumatology)

·      to validate on CT-scan, structural damages on vertebral bodies and posterior articular joints in a population of SpA followed -up in the department from 2008 to 2018.

·      to evaluate on CT scan structural damages differences on spine between axial psoriatic arthritis (PsA) and SpA patients.  To compare the performance of CT-scan to the radiography considered as the gold standard of the medical imaging.

·      to measure the CT attenuation values of lumbar vertebrae, reflecting the mineralization of the trabecular bone, and considered as a promising method to   depict osteoporosis. These measurements are performed on OsiriX software on the selected population of SpA, axial PsA (2008-2018).

Longitudinal study

In SpA patients (AS, axial PsA) for whom at least two CT scans were performed we proposed:

·      to determine the percentage of patients presenting structural progression on CT-scan and on radiography

o   Predictive factors of structural progression clinic biologic and therapeutic.

·      to measure the CT attenuation values of the lumbar vertebrae during the follow-up

o   Predictive factors (clinic biologic and therapeutic) related with variation of the CA.

Profile: We are looking for an enthusiastic, creative and independent postdoctoral researcher with:

·       a PhD in a relevant domain.

  • Profound expertise in Computed Tomography, MRI and in image processing or computer vision.
  • Interest in a multidisciplinary project and in medical imaging.
  • Skills in medical imaging and anatomical and functional image processing experimental and clinical applications of imaging technology, applied/statistical mathematics will be particularly appreciated.
  • An innovative spirit and team player skills round off the profile.
  • Good communication skills (oral and written).

Applicant: We look forward to receiving your application including a cover letter, a detailed CV, and 2 letters of recommendation by email to the three indicated contacts.